Sandbox Reserved 1787
From Proteopedia
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===Significance and Background=== | ===Significance and Background=== | ||
| + | IgM is one of multiple types of Ig that exist in humans. IgM presents itself on the surface of a B cell as a B Cell Receptor (BCR). Upon binding of an antigen to the BCR, the B cell will activate, proliferate, and produce other Ig compounds. These include IgG, IgD, IgA, and IgE [https://proteopedia.org/wiki/index.php/Antibody antibodies] which all have different roles in the various forms of imune response. This means that the IgM BCR is a critical step in the beggining of an imune response. | ||
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| + | The structure of IgM was found using [https://www.thermofisher.com/us/en/home/electron-microscopy/life-sciences/protein-analysis.html Cryo-EM] to visualize each atom in the protein. | ||
===History and Discovery=== | ===History and Discovery=== | ||
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The constant region of IgM is made up of the 2 <scene name='95/952715/Heavy_chain/1'>heavy chains</scene>. Theese heavy chains form a bridge connecting the FAB fragment or variable region to the transmembrane region. They also act as a wire that the variable region can send a signal through to the intermembrane region as a cellular signal that an antigen has bound. | The constant region of IgM is made up of the 2 <scene name='95/952715/Heavy_chain/1'>heavy chains</scene>. Theese heavy chains form a bridge connecting the FAB fragment or variable region to the transmembrane region. They also act as a wire that the variable region can send a signal through to the intermembrane region as a cellular signal that an antigen has bound. | ||
| - | <scene name='95/952715/Alpha_beta_heavy/2'>Alpha, Beta, and Heavy chain interactions</scene> | + | <scene name='95/952715/Alpha_beta_heavy/2'>Alpha, Beta, and Heavy chain interactions</scene> help hold the heavy chains and Ig Alpha/Beta chains together in the estracellular portion of the intermembrane region. |
===Variable Region=== | ===Variable Region=== | ||
Revision as of 23:55, 4 April 2023
| This Sandbox is Reserved from February 27 through August 31, 2023 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1765 through Sandbox Reserved 1795. |
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Human B-cell Antigen Receptor: IgM BCR
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