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1ken

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[[Image:1ken.gif|left|200px]]
[[Image:1ken.gif|left|200px]]
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{{Structure
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|PDB= 1ken |SIZE=350|CAPTION= <scene name='initialview01'>1ken</scene>, resolution 3.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1ken", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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{{STRUCTURE_1ken| PDB=1ken | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ken FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ken OCA], [http://www.ebi.ac.uk/pdbsum/1ken PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ken RCSB]</span>
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}}
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'''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION'''
'''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION'''
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[[Category: Skehel, J J.]]
[[Category: Skehel, J J.]]
[[Category: Wharto, S A.]]
[[Category: Wharto, S A.]]
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[[Category: envelope protein]]
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[[Category: Envelope protein]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hemagglutinin]]
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[[Category: Hemagglutinin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:38:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:47:30 2008''
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Revision as of 19:38, 2 May 2008

Image:1ken.gif

Template:STRUCTURE 1ken

INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION


Overview

We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.

About this Structure

1KEN is a Protein complex structure of sequences from Influenza a virus and Mus musculus. Full crystallographic information is available from OCA.

Reference

An antibody that prevents the hemagglutinin low pH fusogenic transition., Barbey-Martin C, Gigant B, Bizebard T, Calder LJ, Wharton SA, Skehel JJ, Knossow M, Virology. 2002 Mar 1;294(1):70-4. PMID:11886266 Page seeded by OCA on Fri May 2 22:38:56 2008

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