1kex
From Proteopedia
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'''Crystal Structure of the b1 Domain of Human Neuropilin-1''' | '''Crystal Structure of the b1 Domain of Human Neuropilin-1''' | ||
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[[Category: Ng, K.]] | [[Category: Ng, K.]] | ||
[[Category: Spraggon, G.]] | [[Category: Spraggon, G.]] | ||
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Revision as of 19:39, 2 May 2008
Crystal Structure of the b1 Domain of Human Neuropilin-1
Overview
Neuropilin-1 (Npn-1) is a type I cell surface receptor involved in a broad range of developmental processes, including axon guidance, angiogenesis, and heterophilic cell adhesion. We have determined the crystal structure of the human Npn-1 b1 domain to 1.9 A. The overall structure resembles coagulation factor V and VIII (F5/8) C1 and C2 domains, exhibiting a distorted jellyroll fold. Details of the structure provide insight to b1 domain regions responsible for ligand binding and facilitate rationalization of existing biochemical binding data. A polar cleft formed by adjacent loops at one end of the molecule in conjunction with flanking electronegative surfaces may represent the binding site for the positively charged tails of semaphorins and VEGF(165). The nature of the cell adhesion binding site of the b1 domain can be visualized in context of the structure.
About this Structure
1KEX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the human neuropilin-1 b1 domain., Lee CC, Kreusch A, McMullan D, Ng K, Spraggon G, Structure. 2003 Jan;11(1):99-108. PMID:12517344 Page seeded by OCA on Fri May 2 22:39:37 2008
