7uv1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Vicilin Ana o 1.0101 leader sequence residues 20-75== | |
| + | <StructureSection load='7uv1' size='340' side='right'caption='[[7uv1]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7uv1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anacardium_occidentale Anacardium occidentale]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UV1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uv1 OCA], [https://pdbe.org/7uv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uv1 RCSB], [https://www.ebi.ac.uk/pdbsum/7uv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uv1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8L5L6_ANAOC Q8L5L6_ANAOC] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Peanut and tree-nut allergies are frequently comorbid for reasons not completely understood. Vicilin-buried peptides (VBPs) are an emerging family of food allergens whose conserved structural fold could mediate peanut/tree-nut co-allergy. Peptide microarrays were used to identify immunoglobulin E (IgE) epitopes from the N-terminus of the vicilin allergens Ara h 1, Ana o 1, Jug r 2, and Pis v 3 using serum from three patient diagnosis groups: monoallergic to either peanuts or cashew/pistachio, or dual allergic. IgE binding peptides were highly prevalent in the VBP domains AH1.1, AO1.1, JR2.1, and PV3.1, but not in AO1.2, JR2.2, JR2.3, and PV3.2 nor the unstructured regions. The IgE profiles did not correlate with diagnosis group. The structure of the VBPs from cashew and pistachio was solved using solution-NMR. Comparisons of structural features suggest that the VBP scaffold from peanuts and tree-nuts can support cross-reactivity. This may help understand comorbidity and cross-reactivity despite a distant evolutionary origin. | ||
| - | + | Structure and IgE Cross-Reactivity among Cashew, Pistachio, Walnut, and Peanut Vicilin-Buried Peptides.,Foo ACY, Nesbit JB, Gipson SAY, DeRose EF, Cheng H, Hurlburt BK, Kulis MD, Kim EH, Dreskin SC, Mustafa S, Maleki SJ, Mueller GA J Agric Food Chem. 2023 Feb 15;71(6):2990-2998. doi: 10.1021/acs.jafc.2c07061. , Epub 2023 Feb 2. PMID:36728846<ref>PMID:36728846</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7uv1" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Anacardium occidentale]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: DeRose EF]] | ||
| + | [[Category: Foo ACY]] | ||
| + | [[Category: Mueller GA]] | ||
Revision as of 06:22, 7 April 2023
Vicilin Ana o 1.0101 leader sequence residues 20-75
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