5h4d
From Proteopedia
(Difference between revisions)
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==Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride== | ==Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride== | ||
| - | <StructureSection load='5h4d' size='340' side='right' caption='[[5h4d]], [[Resolution|resolution]] 3.21Å' scene=''> | + | <StructureSection load='5h4d' size='340' side='right'caption='[[5h4d]], [[Resolution|resolution]] 3.21Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5h4d]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5h4d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H4D FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BBI:(2-BUTYL-1-BENZOFURAN-3-YL){4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL}METHANONE'>BBI</scene>, <scene name='pdbligand= | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=BBI:(2-BUTYL-1-BENZOFURAN-3-YL){4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL}METHANONE'>BBI</scene>, <scene name='pdbligand=MCM:7-AMINO-4-METHYL-CHROMEN-2-ONE'>MCM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h4d OCA], [https://pdbe.org/5h4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h4d RCSB], [https://www.ebi.ac.uk/pdbsum/5h4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h4d ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Fu | + | [[Category: Large Structures]] |
| - | [[Category: Liu | + | [[Category: Fu L]] |
| - | [[Category: Liu | + | [[Category: Liu B]] |
| - | [[Category: Zhang | + | [[Category: Liu J]] |
| - | + | [[Category: Zhang S]] | |
| - | + | ||
Current revision
Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride
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Categories: Homo sapiens | Large Structures | Fu L | Liu B | Liu J | Zhang S
