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4w9w

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==Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762==
==Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762==
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<StructureSection load='4w9w' size='340' side='right' caption='[[4w9w]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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<StructureSection load='4w9w' size='340' side='right'caption='[[4w9w]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4w9w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4w9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=YDJ:5-(3-FLUOROPHENYL)-N-[(3S)-3-PIPERIDYL]-3-UREIDO-THIOPHENE-2-CARBOXAMIDE'>YDJ</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=YDJ:5-(3-FLUOROPHENYL)-N-[(3S)-3-PIPERIDYL]-3-UREIDO-THIOPHENE-2-CARBOXAMIDE'>YDJ</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BMP2K, BIKE, HRIHFB2017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9w OCA], [https://pdbe.org/4w9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9w RCSB], [https://www.ebi.ac.uk/pdbsum/4w9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9w ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9w OCA], [http://pdbe.org/4w9w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w9w RCSB], [http://www.ebi.ac.uk/pdbsum/4w9w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9w ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN]] May be involved in osteoblast differentiation.
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[https://www.uniprot.org/uniprot/BMP2K_HUMAN BMP2K_HUMAN] May be involved in osteoblast differentiation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Delft, F von]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Savitsky P]]
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[[Category: Structural genomic]]
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[[Category: Sorrell FJ]]
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[[Category: Savitsky, P]]
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[[Category: Williams E]]
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[[Category: Sorrell, F J]]
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[[Category: Von Delft F]]
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[[Category: Williams, E]]
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[[Category: Catalytic domain]]
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[[Category: Inhibitor]]
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[[Category: Kinase]]
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[[Category: Protein binding]]
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[[Category: Sgc]]
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[[Category: Small-molecule]]
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[[Category: Transferase]]
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Revision as of 06:58, 7 April 2023

Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762

PDB ID 4w9w

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