4wa3

From Proteopedia

(Difference between revisions)

Revision as of 06:59, 7 April 2023

The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals

Structural highlights

4wa3 is a 1 chain structure with sequence from Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

I6NW33_9INFA Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]

Publication Abstract from PubMed

In late 2011, an A(H3N8) influenza virus infection resulted in the deaths of 162 New England harbor seals. Virus sequence analysis and virus receptor binding studies highlighted potential markers responsible for mammalian adaptation and a mixed receptor binding preference (Anthony et al. ; MBio 3: e00166-00112). Here we present a detailed structural and biochemical analysis of the surface antigens of this virus. Results obtained with recombinant proteins for both the hemagglutinin and neuraminidase, indicate a true avian receptor binding preference. Although the detection of this virus in new species highlights an increased potential for cross-species transmission with these viruses, our results indicate that the A(H3N8) virus currently poses a low risk to humans. IMPORTANCE: Cross-species transmission of zoonotic influenza viruses increases public health concerns. Here we report a molecular and structural study of the major surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals. Results improve our understanding of these viruses as they evolve and provide important information to aid ongoing risk assessment analyses, as these zoonotic influenza viruses continue to circulate and adapt to new hosts.

Structural and functional analysis of surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals.,Yang H, Nguyen HT, Carney PJ, Guo Z, Chang JC, Jones J, Davis CT, Villanueva JM, Gubareva LV, Stevens J J Virol. 2014 Dec 24. pii: JVI.02723-14. PMID:25540377^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Yang H, Nguyen HT, Carney PJ, Guo Z, Chang JC, Jones J, Davis CT, Villanueva JM, Gubareva LV, Stevens J. Structural and functional analysis of surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals. J Virol. 2014 Dec 24. pii: JVI.02723-14. PMID:25540377 doi:http://dx.doi.org/10.1128/JVI.02723-14

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4wa3"

Categories: Large Structures | Gubareva LV | Stevens J | Villanueva JM | Yang H

@@ Line 1: / Line 1: @@
 ==The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals==
-<StructureSection load='4wa3' size='340' side='right' caption='[[4wa3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='4wa3' size='340' side='right'caption='[[4wa3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4wa3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/harbor_seal/massachusetts/1/2011(h3n8)) Influenza a virus (a/harbor seal/massachusetts/1/2011(h3n8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WA3 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4wa3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/harbor_seal/Massachusetts/1/2011(H3N8)) Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WA3 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wa1|4wa1]], [[4wa2|4wa2]], [[4wa4|4wa4]], [[4wa5|4wa5]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wa3 OCA], [https://pdbe.org/4wa3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wa3 RCSB], [https://www.ebi.ac.uk/pdbsum/4wa3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wa3 ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1136533 Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wa3 OCA], [http://pdbe.org/4wa3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wa3 RCSB], [http://www.ebi.ac.uk/pdbsum/4wa3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wa3 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/I6NW33_9INFA I6NW33_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
+[https://www.uniprot.org/uniprot/I6NW33_9INFA I6NW33_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 18: @@
 </div>
 <div class="pdbe-citations 4wa3" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Gubareva, L V]]
+[[Category: Large Structures]]
-[[Category: Stevens, J]]
+[[Category: Gubareva LV]]
-[[Category: Villanueva, J M]]
+[[Category: Stevens J]]
-[[Category: Yang, H]]
+[[Category: Villanueva JM]]
-[[Category: Influenza virus]]
+[[Category: Yang H]]
-[[Category: Neuraminidase]]
-[[Category: Seal]]
-[[Category: Viral protein]]

4wa3

From Proteopedia

Revision as of 06:59, 7 April 2023

The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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