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4wa8

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<StructureSection load='4wa8' size='340' side='right'caption='[[4wa8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4wa8' size='340' side='right'caption='[[4wa8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wa8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Metka Metka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WA8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wa8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanopyrus_kandleri_AV19 Methanopyrus kandleri AV19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WA8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fen, MK0566 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=190192 METKA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wa8 OCA], [https://pdbe.org/4wa8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wa8 RCSB], [https://www.ebi.ac.uk/pdbsum/4wa8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wa8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wa8 OCA], [http://pdbe.org/4wa8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wa8 RCSB], [http://www.ebi.ac.uk/pdbsum/4wa8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wa8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FEN_METKA FEN_METKA]] Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
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[https://www.uniprot.org/uniprot/FEN_METKA FEN_METKA] Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Endonuclease|Endonuclease]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Metka]]
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[[Category: Methanopyrus kandleri AV19]]
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[[Category: Dunten, P]]
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[[Category: Dunten P]]
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[[Category: Horton, N C]]
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[[Category: Horton NC]]
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[[Category: Shah, S]]
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[[Category: Shah S]]
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[[Category: Dna nuclease]]
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[[Category: Hydrolase]]
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[[Category: Nucleotide excision repair]]
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Revision as of 06:59, 7 April 2023

Methanopyrus Kandleri FEN-1 nuclease

PDB ID 4wa8

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