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4wab

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<StructureSection load='4wab' size='340' side='right'caption='[[4wab]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4wab' size='340' side='right'caption='[[4wab]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wab]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WAB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WAB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wab]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WAB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LVJ:2-[[2,6-BIS(CHLORANYL)-3-[(2,2-DIMETHYLPROPANOYLAMINO)METHYL]PHENYL]AMINO]-1-METHYL-6-(2-METHYL-2-OXIDANYL-PROPOXY)-N-[2,2,2-TRIS(FLUORANYL)ETHYL]BENZIMIDAZOLE-5-CARBOXAMIDE'>LVJ</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LVJ:2-[[2,6-BIS(CHLORANYL)-3-[(2,2-DIMETHYLPROPANOYLAMINO)METHYL]PHENYL]AMINO]-1-METHYL-6-(2-METHYL-2-OXIDANYL-PROPOXY)-N-[2,2,2-TRIS(FLUORANYL)ETHYL]BENZIMIDAZOLE-5-CARBOXAMIDE'>LVJ</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LTC4S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wab OCA], [https://pdbe.org/4wab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wab RCSB], [https://www.ebi.ac.uk/pdbsum/4wab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wab ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wab OCA], [http://pdbe.org/4wab PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wab RCSB], [http://www.ebi.ac.uk/pdbsum/4wab PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wab ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN]] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Prostaglandin-E synthase]]
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[[Category: Caffrey M]]
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[[Category: Caffrey, M]]
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[[Category: Howe N]]
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[[Category: Howe, N]]
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[[Category: Li D]]
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[[Category: Li, D]]
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[[Category: Wang M]]
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[[Category: Wang, M]]
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[[Category: Weinert T]]
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[[Category: Weinert, T]]
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[[Category: Anomalous dispersion]]
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[[Category: Cancer]]
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[[Category: Drug target]]
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[[Category: In meso crystallization]]
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[[Category: Inflammation]]
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[[Category: Inhibitor]]
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[[Category: Isomerase]]
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[[Category: Leukotriene c4 synthase]]
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[[Category: Lipid metabolism]]
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[[Category: Mapag]]
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[[Category: Membrane protein]]
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[[Category: Membrane-associated proteins in eicosanoid and glutathione metabolism]]
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[[Category: Microcrystal]]
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[[Category: Mpges1]]
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[[Category: Native-sad]]
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[[Category: Pain]]
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[[Category: S-sad]]
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[[Category: Sulfur-sad]]
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Revision as of 06:59, 7 April 2023

Crystal structure of mPGES1 solved by native-SAD phasing

PDB ID 4wab

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