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4wev

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<StructureSection load='4wev' size='340' side='right'caption='[[4wev]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='4wev' size='340' side='right'caption='[[4wev]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wev]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WEV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WEV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wev]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WEV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SUZ:[(1Z)-5-FLUORO-2-METHYL-1-{4-[METHYLSULFINYL]BENZYLIDENE}-1H-INDEN-3-YL]ACETIC+ACID'>SUZ</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SUZ:[(1Z)-5-FLUORO-2-METHYL-1-{4-[METHYLSULFINYL]BENZYLIDENE}-1H-INDEN-3-YL]ACETIC+ACID'>SUZ</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wev OCA], [https://pdbe.org/4wev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wev RCSB], [https://www.ebi.ac.uk/pdbsum/4wev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wev ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zua|1zua]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B10, AKR1B11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wev OCA], [http://pdbe.org/4wev PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wev RCSB], [http://www.ebi.ac.uk/pdbsum/4wev PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wev ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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[https://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cousido-Siah, A]]
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[[Category: Cousido-Siah A]]
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[[Category: Crespo, I]]
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[[Category: Crespo I]]
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[[Category: Farres, J]]
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[[Category: Farres J]]
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[[Category: Mitschler, A]]
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[[Category: Mitschler A]]
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[[Category: Pares, X]]
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[[Category: Pares X]]
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[[Category: Podjarny, A]]
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[[Category: Podjarny A]]
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[[Category: Porte, S]]
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[[Category: Porte S]]
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[[Category: Ruiz, F X]]
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[[Category: Ruiz FX]]
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[[Category: Aldo-keto reductase]]
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[[Category: Ari]]
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[[Category: Carboxylic type]]
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[[Category: Cytosolic]]
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[[Category: Oxidoreductase]]
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[[Category: Tim barrel]]
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Revision as of 07:05, 7 April 2023

Crystal structure of human AKR1B10 complexed with NADP+ and sulindac

PDB ID 4wev

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