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4wpx

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Revision as of 07:20, 7 April 2023

Chaetomium theromophilum TREX2 CID domain complex

Structural highlights

4wpx is a 6 chain structure with sequence from Chaetomium thermophilum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G0SAR7_CHATD

Publication Abstract from PubMed

The TREX-2 complex integrates mRNA nuclear export into the gene expression pathway and is based on a Sac3 scaffold to which Thp1, Sem1, Sus1, and Cdc31 bind. TREX-2 also binds the mRNA nuclear export factor, Mex67:Mtr2, through the Sac3 N-terminal region (Sac3N). Here, we characterize Chaetomium thermophilum TREX-2, show that the in vitro reconstituted complex has an annular structure, and define the structural basis for interactions between Sac3, Sus1, Cdc31, and Mex67:Mtr2. Crystal structures show that the binding of C. thermophilum Sac3N to the Mex67 NTF2-like domain (Mex67NTF2L) is mediated primarily through phenylalanine residues present in a series of repeating sequence motifs that resemble those seen in many nucleoporins, and Mlp1 also binds Mex67:Mtr2 using a similar motif. Deletion of Sac3N generated growth and mRNA export defects in Saccharomyces cerevisiae, and we propose TREX-2 and Mlp1 function to facilitate export by concentrating mature messenger ribonucleoparticles at the nuclear pore entrance.

Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.,Dimitrova L, Valkov E, Aibara S, Flemming D, McLaughlin SH, Hurt E, Stewart M Structure. 2015 Jun 3. pii: S0969-2126(15)00180-X. doi:, 10.1016/j.str.2015.05.002. PMID:26051714^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Dimitrova L, Valkov E, Aibara S, Flemming D, McLaughlin SH, Hurt E, Stewart M. Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2. Structure. 2015 Jun 3. pii: S0969-2126(15)00180-X. doi:, 10.1016/j.str.2015.05.002. PMID:26051714 doi:http://dx.doi.org/10.1016/j.str.2015.05.002

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4wpx"

Categories: Chaetomium thermophilum | Large Structures | Stewart M | Valkov E

@@ Line 3: / Line 3: @@
 <StructureSection load='4wpx' size='340' side='right'caption='[[4wpx]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4wpx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WPX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4wpx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WPX FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wpx OCA], [http://pdbe.org/4wpx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wpx RCSB], [http://www.ebi.ac.uk/pdbsum/4wpx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wpx ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wpx OCA], [https://pdbe.org/4wpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wpx RCSB], [https://www.ebi.ac.uk/pdbsum/4wpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wpx ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/G0SAR7_CHATD G0SAR7_CHATD]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Cbs 144 50]]
+[[Category: Chaetomium thermophilum]]
 [[Category: Large Structures]]
-[[Category: Stewart, M]]
+[[Category: Stewart M]]
-[[Category: Valkov, E]]
+[[Category: Valkov E]]
-[[Category: Cell cycle]]
-[[Category: Mrna nuclear export]]

4wpx

From Proteopedia

Revision as of 07:20, 7 April 2023

Chaetomium theromophilum TREX2 CID domain complex

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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