Sandbox Reserved 1802

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== Biological relevance and broader implications ==
== Biological relevance and broader implications ==
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Enzymes involved in this pathway are potential targets for the development of new antibiotics via this pathway, and enzymes that convert chorismate are promising targets for potential antimicrobials and herbicides.
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Enzymes involved in this pathway are potential targets for the development of new antibiotics via this pathway, and enzymes that convert chorismate are <scene name='95/954099/Protein_view_2/5'>promising targets for potential antimicrobials and herbicides.</scene>
== Important amino acids==
== Important amino acids==
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The three amnio acids involved in the catalytic triad ar<scene name='95/954099/Catalytic_triad/1'>e N17,S86, and Y242</scene>.
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The three amnio acids involved in the catalytic triad are N17, S86, and Y242.
Important amino acids for binding are the following: I13, N17, C18, P41, E42, V58, V84, S86, C87, S109, R110, T111, S112, I150, G151, F186, Y242
Important amino acids for binding are the following: I13, N17, C18, P41, E42, V58, V84, S86, C87, S109, R110, T111, S112, I150, G151, F186, Y242

Revision as of 19:47, 8 April 2023

This Sandbox is Reserved from Mar 1 through Jun 1, 2023 for use in the course CHEM 351 Biochemistry taught by Bonnie_Hall at the Grand View University, Des Moines, USA. This reservation includes Sandbox Reserved 1796 through Sandbox Reserved 1811.
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Chorismate dehydratase (MqnA)

Caption for this structure

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References

[3]

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Prasad A, Breithaupt C, Nguyen DA, Lilie H, Ziegler J, Stubbs MT. Mechanism of chorismate dehydratase MqnA, the first enzyme of the futalosine pathway, proceeds via substrate-assisted catalysis. J Biol Chem. 2022 Dec;298(12):102601. PMID:36265588 doi:10.1016/j.jbc.2022.102601
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