Sandbox Reserved 1802

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Function of your protein

The specific function of my protein is catalyzing the dehydration of chorismate to yield 3-enolpyruvyl-benzoate (3-EPB), which is the initial step in the biosynthesis of menaquinone via the futalosine pathway.

Biological relevance and broader implications

Enzymes involved in this pathway are potential targets for the development of new antibiotics via this pathway, and enzymes that convert chorismate are

Important amino acids

The three amnio acids involved in the catalytic triad are N17, S86, and Y242.

Important amino acids for binding are the following: I13, N17, C18, P41, E42, V58, V84, S86, C87, S109, R110, T111, S112, I150, G151, F186, Y242

Structural highlights

The Secondary structures has roughly 19 beta sheets, 27 alpha helices, and several random coils. The tertiary structure would be described as globular as is it in a shape of a ball, with an alpha clamp and two lobes connected by two linkers. The beta sheets contain all three of the catalytic amino acids and most of the important binding amino acids.