8anp

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m (Protected "8anp" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8anp is ON HOLD until Paper Publication
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==Legionella effector Lem3 mutant D190A in complex with Mg2+==
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<StructureSection load='8anp' size='340' side='right'caption='[[8anp]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Kaspers, M.S., Pogenberg, V., Ernst, S., Ecker, F., Pett, C., Ochtrop, P., Hedberg, C., Groll, M., Itzen, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8anp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ANP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ANP FirstGlance]. <br>
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Description: Legionella effector Lem3 mutant D190A in complex with Mg2+
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8anp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8anp OCA], [https://pdbe.org/8anp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8anp RCSB], [https://www.ebi.ac.uk/pdbsum/8anp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8anp ProSAT]</span></td></tr>
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[[Category: Pett, C]]
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</table>
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[[Category: Hedberg, C]]
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== Function ==
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[[Category: Ernst, S]]
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[https://www.uniprot.org/uniprot/LEM3_LEGPH LEM3_LEGPH] Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine hydrolase by mediating the hydrolysis of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C). Dephosphocholination of target proteins restores accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins.<ref>PMID:22158903</ref> <ref>PMID:22307087</ref> <ref>PMID:22411835</ref>
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[[Category: Itzen, A]]
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== References ==
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[[Category: Pogenberg, V]]
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<references/>
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[[Category: Kaspers, M.S]]
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__TOC__
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[[Category: Groll, M]]
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</StructureSection>
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[[Category: Ochtrop, P]]
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[[Category: Large Structures]]
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[[Category: Ecker, F]]
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[[Category: Legionella pneumophila]]
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[[Category: Ecker F]]
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[[Category: Ernst S]]
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[[Category: Groll M]]
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[[Category: Hedberg C]]
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[[Category: Itzen A]]
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[[Category: Kaspers MS]]
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[[Category: Ochtrop P]]
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[[Category: Pett C]]
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[[Category: Pogenberg V]]

Revision as of 20:29, 12 April 2023

Legionella effector Lem3 mutant D190A in complex with Mg2+

PDB ID 8anp

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