8bpe

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'''Unreleased structure'''
 
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The entry 8bpe is ON HOLD until Paper Publication
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==8:1 binding of FcMR on IgM pentameric core==
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<StructureSection load='8bpe' size='340' side='right'caption='[[8bpe]], [[Resolution|resolution]] 3.63&Aring;' scene=''>
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Authors: Chen, Q., Rosenthal, P., Tolar, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8bpe]] is a 19 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPE FirstGlance]. <br>
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Description: 8:1 binding of FcMR on IgM pentameric core
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpe OCA], [https://pdbe.org/8bpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpe RCSB], [https://www.ebi.ac.uk/pdbsum/8bpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpe ProSAT]</span></td></tr>
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[[Category: Rosenthal, P]]
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</table>
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[[Category: Chen, Q]]
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== Function ==
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[[Category: Tolar, P]]
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[https://www.uniprot.org/uniprot/FAIM3_HUMAN FAIM3_HUMAN] May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.<ref>PMID:9586636</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen Q]]
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[[Category: Rosenthal P]]
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[[Category: Tolar P]]

Revision as of 20:30, 12 April 2023

8:1 binding of FcMR on IgM pentameric core

PDB ID 8bpe

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