1kil

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1kil.gif|left|200px]]
[[Image:1kil.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1kil |SIZE=350|CAPTION= <scene name='initialview01'>1kil</scene>, resolution 2.30&Aring;
+
The line below this paragraph, containing "STRUCTURE_1kil", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= Synaptobrevin 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), Syntaxin 1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), SNAP-25 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Complexin 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1kil| PDB=1kil | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kil OCA], [http://www.ebi.ac.uk/pdbsum/1kil PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kil RCSB]</span>
+
-
}}
+
'''Three-dimensional structure of the complexin/SNARE complex'''
'''Three-dimensional structure of the complexin/SNARE complex'''
Line 33: Line 30:
[[Category: Sudhof, T C.]]
[[Category: Sudhof, T C.]]
[[Category: Tomchick, D.]]
[[Category: Tomchick, D.]]
-
[[Category: helix bound to four helix bundle]]
+
[[Category: Helix bound to four helix bundle]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:47:27 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:49:07 2008''
+

Revision as of 19:47, 2 May 2008

Image:1kil.gif

Template:STRUCTURE 1kil

Three-dimensional structure of the complexin/SNARE complex


Overview

During neurotransmitter release, the neuronal SNARE proteins synaptobrevin/VAMP, syntaxin, and SNAP-25 form a four-helix bundle, the SNARE complex, that pulls the synaptic vesicle and plasma membranes together possibly causing membrane fusion. Complexin binds tightly to the SNARE complex and is essential for efficient Ca(2+)-evoked neurotransmitter release. A combined X-ray and TROSY-based NMR study now reveals the atomic structure of the complexin/SNARE complex. Complexin binds in an antiparallel alpha-helical conformation to the groove between the synaptobrevin and syntaxin helices. This interaction stabilizes the interface between these two helices, which bears the repulsive forces between the apposed membranes. These results suggest that complexin stabilizes the fully assembled SNARE complex as a key step that enables the exquisitely high speed of Ca(2+)-evoked neurotransmitter release.

About this Structure

1KIL is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the complexin/SNARE complex., Chen X, Tomchick DR, Kovrigin E, Arac D, Machius M, Sudhof TC, Rizo J, Neuron. 2002 Jan 31;33(3):397-409. PMID:11832227 Page seeded by OCA on Fri May 2 22:47:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kil"
Personal tools