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| | ==CRYSTAL STRUCTURE OF CENP-C IN COMPLEX WITH THE NUCLEOSOME CORE PARTICLE== | | ==CRYSTAL STRUCTURE OF CENP-C IN COMPLEX WITH THE NUCLEOSOME CORE PARTICLE== |
| - | <StructureSection load='4x23' size='340' side='right' caption='[[4x23]], [[Resolution|resolution]] 3.50Å' scene=''> | + | <StructureSection load='4x23' size='340' side='right'caption='[[4x23]], [[Resolution|resolution]] 3.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4x23]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Drome Drome]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4inm 4inm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X23 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4x23]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4inm 4inm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X23 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4inm|4inm]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x23 OCA], [https://pdbe.org/4x23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x23 RCSB], [https://www.ebi.ac.uk/pdbsum/4x23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x23 ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">His3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), His4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), His2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), His2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x23 OCA], [http://pdbe.org/4x23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x23 RCSB], [http://www.ebi.ac.uk/pdbsum/4x23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x23 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/H2A_DROME H2A_DROME] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 4x23" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 4x23" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Histone 3D structures|Histone 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Drome]] | + | [[Category: Drosophila melanogaster]] |
| - | [[Category: Jiang, J S]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Cenp-c complex]] | + | [[Category: Large Structures]] |
| - | [[Category: Chromosome centromere]] | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Histone fold]] | + | [[Category: Jiang JS]] |
| - | [[Category: Kinetochore assembly]]
| + | |
| - | [[Category: Nucleosome core particle]]
| + | |
| - | [[Category: Segregation]]
| + | |
| - | [[Category: Structural protein-dna complex]]
| + | |
| - | [[Category: Widom 601 dna fragmment]]
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| Structural highlights
Function
H2A_DROME
Publication Abstract from PubMed
Chromosome segregation during mitosis requires assembly of the kinetochore complex at the centromere. Kinetochore assembly depends on specific recognition of the histone variant CENP-A in the centromeric nucleosome by centromere protein C (CENP-C). We have defined the determinants of this recognition mechanism and discovered that CENP-C binds a hydrophobic region in the CENP-A tail and docks onto the acidic patch of histone H2A and H2B. We further found that the more broadly conserved CENP-C motif uses the same mechanism for CENP-A nucleosome recognition. Our findings reveal a conserved mechanism for protein recruitment to centromeres and a histone recognition mode whereby a disordered peptide binds the histone tail through hydrophobic interactions facilitated by nucleosome docking.
A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C.,Kato H, Jiang J, Zhou BR, Rozendaal M, Feng H, Ghirlando R, Xiao TS, Straight AF, Bai Y Science. 2013 May 31;340(6136):1110-3. doi: 10.1126/science.1235532. PMID:23723239[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Kato H, Jiang J, Zhou BR, Rozendaal M, Feng H, Ghirlando R, Xiao TS, Straight AF, Bai Y. A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. Science. 2013 May 31;340(6136):1110-3. doi: 10.1126/science.1235532. PMID:23723239 doi:10.1126/science.1235532
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