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Tenofovir

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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='96/960003/Cv/1'>
<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='96/960003/Cv/1'>
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Tenofovir disoproxil, sold under the trade name Viread among others, is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. See also [https://en.wikipedia.org/wiki/Tenofovir_disoproxil].
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Efavirenz/emtricitabine/tenofovir, sold under the brand name Atripla among others, is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. It contains [[efavirenz]], [[emtricitabine]], and [[tenofovir disoproxil]]. It can be used by itself or together with other antiretroviral medications.
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Tenofovir disoproxil is a prodrug that is quickly absorbed from the gut and cleaved to release tenofovir. Inside cells, tenofovir is phosphorylated to tenofovir diphosphate (which is analogous to a triphosphate, as tenofovir itself already has one phosphonate residue), the active compound that inhibits reverse transcriptase via chain termination.
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<scene name='96/960003/Cv/3'>Tenofovir diphosphate (TNV) binding site</scene> at reverse transcriptase ([[3fkb]]). Water molecules are shown as red spheres.
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<scene name='96/960003/Tnmbindingsite/5'>Tenofovir-monophosphate (TNM) binding site</scene> at reverse transcriptase ([[3fkb]]).
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</StructureSection>
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== References ==
== References ==
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Revision as of 13:28, 16 April 2023

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