Tenofovir
From Proteopedia
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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='96/960003/Cv/1'> | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='96/960003/Cv/1'> | ||
| + | Tenofovir disoproxil, sold under the trade name Viread among others, is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. See also [https://en.wikipedia.org/wiki/Tenofovir_disoproxil]. | ||
| + | Tenofovir disoproxil is a prodrug that is quickly absorbed from the gut and cleaved to release tenofovir. Inside cells, tenofovir is phosphorylated to tenofovir diphosphate (which is analogous to a triphosphate, as tenofovir itself already has one phosphonate residue), the active compound that inhibits reverse transcriptase via chain termination. | ||
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| + | <scene name='96/960003/Cv/3'>Tenofovir diphosphate (TNV) binding site</scene> at reverse transcriptase ([[3fkb]]). Water molecules are shown as red spheres. | ||
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| + | <scene name='96/960003/Tnmbindingsite/5'>Tenofovir-monophosphate (TNM) binding site</scene> at reverse transcriptase ([[3fkb]]). | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 13:31, 16 April 2023
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