1kko

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[[Image:1kko.gif|left|200px]]
[[Image:1kko.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1kko |SIZE=350|CAPTION= <scene name='initialview01'>1kko</scene>, resolution 1.33&Aring;
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The line below this paragraph, containing "STRUCTURE_1kko", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylaspartate_ammonia-lyase Methylaspartate ammonia-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.2 4.3.1.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= MAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=35703 Citrobacter amalonaticus])
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|DOMAIN=
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{{STRUCTURE_1kko| PDB=1kko | SCENE= }}
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|RELATEDENTRY=[[1kkr|1KKR]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kko OCA], [http://www.ebi.ac.uk/pdbsum/1kko PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kko RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF CITROBACTER AMALONATICUS METHYLASPARTATE AMMONIA LYASE'''
'''CRYSTAL STRUCTURE OF CITROBACTER AMALONATICUS METHYLASPARTATE AMMONIA LYASE'''
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[[Category: Rice, D W.]]
[[Category: Rice, D W.]]
[[Category: Sedelnikova, S.]]
[[Category: Sedelnikova, S.]]
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[[Category: enolase superfamily]]
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[[Category: Enolase superfamily]]
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[[Category: methylaspartate ammonia lyase]]
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[[Category: Methylaspartate ammonia lyase]]
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[[Category: tim barrel]]
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[[Category: Tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:51:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:49:53 2008''
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Revision as of 19:51, 2 May 2008

Image:1kko.gif

Template:STRUCTURE 1kko

CRYSTAL STRUCTURE OF CITROBACTER AMALONATICUS METHYLASPARTATE AMMONIA LYASE


Overview

Methylaspartate ammonia lyase (MAL) catalyzes the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. The 1.3 A MAD crystal structure of the dimeric Citrobacter amalonaticus MAL shows that each subunit comprises two domains, one of which adopts the classical TIM barrel fold, with the active site at the C-terminal end of the barrel. Despite very low sequence similarity, the structure of MAL is closely related to those of representative members of the enolase superfamily, indicating that the mechanism of MAL involves the initial abstraction of a proton alpha to the 3-carboxyl of (2S,3S)-3-methylasparic acid to yield an enolic intermediate. This analysis resolves the conflict that had linked MAL to the histidine and phenylalanine ammonia lyase family of enzymes.

About this Structure

1KKO is a Single protein structure of sequence from Citrobacter amalonaticus. Full crystallographic information is available from OCA.

Reference

Insights into enzyme evolution revealed by the structure of methylaspartate ammonia lyase., Levy CW, Buckley PA, Sedelnikova S, Kato Y, Asano Y, Rice DW, Baker PJ, Structure. 2002 Jan;10(1):105-13. PMID:11796115 Page seeded by OCA on Fri May 2 22:51:27 2008

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