7qpm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate== | |
| - | + | <StructureSection load='7qpm' size='340' side='right'caption='[[7qpm]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7qpm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QPM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EEI:5,7-dimethyl-2-[(1-methyl-4-phenyl-imidazol-2-yl)sulfanylmethyl]imidazo[1,2-a]pyrimidine'>EEI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qpm OCA], [https://pdbe.org/7qpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qpm RCSB], [https://www.ebi.ac.uk/pdbsum/7qpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qpm ProSAT]</span></td></tr> |
| - | [[Category: Langgard | + | </table> |
| - | [[Category: Leonard | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Langgard M]] | ||
| + | [[Category: Leonard PM]] | ||
Revision as of 09:19, 19 April 2023
Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate
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