1kku

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1kku.jpg|left|200px]]
[[Image:1kku.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1kku |SIZE=350|CAPTION= <scene name='initialview01'>1kku</scene>, resolution 2.5&Aring;
+
The line below this paragraph, containing "STRUCTURE_1kku", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide-nucleotide_adenylyltransferase Nicotinamide-nucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.1 2.7.7.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1kku| PDB=1kku | SCENE= }}
-
|RELATEDENTRY=[[1f9a|1f9a]], [[1ej2|1ej2]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kku OCA], [http://www.ebi.ac.uk/pdbsum/1kku PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kku RCSB]</span>
+
-
}}
+
'''Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase'''
'''Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase'''
Line 33: Line 30:
[[Category: Pierella, F.]]
[[Category: Pierella, F.]]
[[Category: Rizzi, M.]]
[[Category: Rizzi, M.]]
-
[[Category: alpha/beta structure - rossmann fold]]
+
[[Category: Alpha/beta structure - rossmann fold]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:51:48 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:50:00 2008''
+

Revision as of 19:51, 2 May 2008

Image:1kku.jpg

Template:STRUCTURE 1kku

Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase


Overview

Nicotinamide mononucleotide adenylyltransferase (NMNAT), a member of the nucleotidyltransferase alpha/beta-phosphodiesterases superfamily, catalyzes a universal step (NMN + ATP = NAD + PP(i)) in NAD biosynthesis. Localized within the nucleus, the activity of the human enzyme is greatly altered in tumor cells, rendering it a promising target for cancer chemotherapy. By using a combination of single isomorphous replacement and density modification techniques, the human NMNAT structure was solved by x-ray crystallography to a 2.5-A resolution, revealing a hexamer that is composed of alpha/beta-topology subunits. The active site topology of the enzyme, analyzed through homology modeling and structural comparison with other NMNATs, yielded convincing evidence for a substrate-induced conformational change. We also observed remarkable structural conservation in the ATP-recognition motifs GXXXPX(T/H)XXH and SXTXXR, which we take to be the universal signature for NMNATs. Structural comparison of human and prokaryotic NMNATs may also lead to the rational design of highly selective antimicrobial drugs.

About this Structure

1KKU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis., Garavaglia S, D'Angelo I, Emanuelli M, Carnevali F, Pierella F, Magni G, Rizzi M, J Biol Chem. 2002 Mar 8;277(10):8524-30. Epub 2001 Dec 19. PMID:11751893 Page seeded by OCA on Fri May 2 22:51:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kku"
Personal tools