8ebt
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (Cy5)== | |
| - | + | <StructureSection load='8ebt' size='340' side='right'caption='[[8ebt]], [[Resolution|resolution]] 3.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ebt]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EBT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=VM6:3-[(2E)-2-{(3Z,5E)-5-[1-(3-hydroxypropyl)-3,3-dimethyl-1,3-dihydro-2H-indol-2-ylidene]pent-3-en-1-ylidene}-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]propyl+dihydrogen+phosphite'>VM6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ebt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ebt OCA], [https://pdbe.org/8ebt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ebt RCSB], [https://www.ebi.ac.uk/pdbsum/8ebt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ebt ProSAT]</span></td></tr> |
| - | [[Category: Kim | + | </table> |
| - | [[Category: Yang | + | == Function == |
| + | [https://www.uniprot.org/uniprot/TF2H2_HUMAN TF2H2_HUMAN] Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Kim J]] | ||
| + | [[Category: Yang W]] | ||
Revision as of 09:26, 19 April 2023
XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (Cy5)
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