8ewi

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'''Unreleased structure'''
 
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The entry 8ewi is ON HOLD until Paper Publication
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==Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form==
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<StructureSection load='8ewi' size='340' side='right'caption='[[8ewi]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors: Wang, F., He, Q., Lin, G., Li, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ewi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EWI FirstGlance]. <br>
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Description: Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ewi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ewi OCA], [https://pdbe.org/8ewi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ewi RCSB], [https://www.ebi.ac.uk/pdbsum/8ewi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ewi ProSAT]</span></td></tr>
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[[Category: Li, H]]
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</table>
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[[Category: Wang, F]]
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== Function ==
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[[Category: He, Q]]
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[https://www.uniprot.org/uniprot/UBR5_HUMAN UBR5_HUMAN] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.<ref>PMID:21127351</ref> <ref>PMID:21726808</ref> <ref>PMID:22884692</ref>
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[[Category: Lin, G]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: He Q]]
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[[Category: Li H]]
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[[Category: Lin G]]
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[[Category: Wang F]]

Revision as of 09:26, 19 April 2023

Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form

PDB ID 8ewi

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