8i9i

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'''Unreleased structure'''
 
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The entry 8i9i is ON HOLD until Paper Publication
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==Glutamyl-tRNA synthetase from Escherichia Coli bound to Glutamate and Zinc==
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<StructureSection load='8i9i' size='340' side='right'caption='[[8i9i]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors: Dev, A., Chongdar, N., Dasgupta, S., Basu, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8i9i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I9I FirstGlance]. <br>
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Description: Glutamyl-tRNA synthetase from Escherichia Coli bound to Glutamate and Zinc
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i9i OCA], [https://pdbe.org/8i9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i9i RCSB], [https://www.ebi.ac.uk/pdbsum/8i9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i9i ProSAT]</span></td></tr>
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[[Category: Dev, A]]
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</table>
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[[Category: Basu, G]]
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== Function ==
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[[Category: Chongdar, N]]
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[https://www.uniprot.org/uniprot/SYE_ECOLI SYE_ECOLI] Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).<ref>PMID:14764088</ref> <ref>PMID:6280993</ref> <ref>PMID:6986385</ref> <ref>PMID:7797500</ref> <ref>PMID:8218204</ref> Phosphorylation of GltX by HipA prevents it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to multidrug resistance and persistence (PubMed:24095282, PubMed:24343429). Overexpression of GltX prevents HipA-induced growth arrest, persister formation and increases in (p)ppGpp levels (PubMed:24343429, PubMed:28430938).<ref>PMID:24095282</ref> <ref>PMID:24343429</ref> <ref>PMID:28430938</ref>
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[[Category: Dasgupta, S]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Basu G]]
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[[Category: Chongdar N]]
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[[Category: Dasgupta S]]
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[[Category: Dev A]]

Revision as of 09:30, 19 April 2023

Glutamyl-tRNA synthetase from Escherichia Coli bound to Glutamate and Zinc

PDB ID 8i9i

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