Sandbox Reserved 1798

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You can see the two-part portion of the protein. The protein has been made somewhat<scene name='95/954095/Color_change/5'> transparent</scene> so you can see the substrate within the ligand.
You can see the two-part portion of the protein. The protein has been made somewhat<scene name='95/954095/Color_change/5'> transparent</scene> so you can see the substrate within the ligand.
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The Chorismate Dehydratatase MqnA is an enzyme that acts upon chorismate, a biochemical intermediate in plants and microorganisms. On the futalosine pathway, it converts chorismate to EPB by removing water.
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The Chorismate Dehydratatase MqnA is an enzyme that acts upon chorismate, a biochemical intermediate in plants and microorganisms. On the futalosine pathway, it converts chorismate to EPB by removing water. MqnA is the only known chorismate dehydratase.
The futalosine pathway biosynthesizes menaquinone, a carrier of electrons in electron transport chain in prokaryotes. Menaquinone is important for a number of functions in the human body, including cell growth control, apoptosis, and the metabolism of calcium, to name a few. As the human body cannot create menaquinone, it derives it from intestinal bacteria, diet, or by converting plant vitamin K1 (phylloquinone).
The futalosine pathway biosynthesizes menaquinone, a carrier of electrons in electron transport chain in prokaryotes. Menaquinone is important for a number of functions in the human body, including cell growth control, apoptosis, and the metabolism of calcium, to name a few. As the human body cannot create menaquinone, it derives it from intestinal bacteria, diet, or by converting plant vitamin K1 (phylloquinone).
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MqnA is the only known chorismate dehydratase.
 
The example we are showing is from Streptomyces coelicolor. The other mutant MqnA are from Escherichia coli.
The example we are showing is from Streptomyces coelicolor. The other mutant MqnA are from Escherichia coli.
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The substrate for MqnA is chorismate. It is converted to menaquinone through two different pathways, the futalosine or the o-succinyl-benzoate pathways. On the futalosine pathway, chorismate is converted to 3-enolpyruvyl-benzoate (3-EPB) by our enzyme of interest.
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== Biological relevance and broader implications ==
== Biological relevance and broader implications ==

Revision as of 03:11, 25 April 2023

This Sandbox is Reserved from Mar 1 through Jun 1, 2023 for use in the course CHEM 351 Biochemistry taught by Bonnie_Hall at the Grand View University, Des Moines, USA. This reservation includes Sandbox Reserved 1796 through Sandbox Reserved 1811.
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Chorismate Dehydratase MqnA

First enzyme on the futalosine pathway, proceeds via substrate assisted catalysis

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References

[3]

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Goubran GF, Adekeye EO, Edwards MB. Melanoma of the face and mouth in Nigeria. A review and comment on three cases. Int J Oral Surg. 1978 Oct;7(5):453-62. PMID:102601 doi:10.1016/s0300-9785(78)80037-4
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