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Sandbox Reserved 1798
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You can see the two-part portion of the protein. The protein has been made somewhat<scene name='95/954095/Color_change/5'> transparent</scene> so you can see the substrate within the ligand. | You can see the two-part portion of the protein. The protein has been made somewhat<scene name='95/954095/Color_change/5'> transparent</scene> so you can see the substrate within the ligand. | ||
| - | The Chorismate Dehydratatase MqnA is an enzyme that acts upon chorismate, a biochemical intermediate in plants and microorganisms. On the futalosine pathway, it converts chorismate to EPB by removing water. | + | The Chorismate Dehydratatase MqnA is an enzyme that acts upon chorismate, a biochemical intermediate in plants and microorganisms. On the futalosine pathway, it converts chorismate to EPB by removing water. MqnA is the only known chorismate dehydratase. |
The futalosine pathway biosynthesizes menaquinone, a carrier of electrons in electron transport chain in prokaryotes. Menaquinone is important for a number of functions in the human body, including cell growth control, apoptosis, and the metabolism of calcium, to name a few. As the human body cannot create menaquinone, it derives it from intestinal bacteria, diet, or by converting plant vitamin K1 (phylloquinone). | The futalosine pathway biosynthesizes menaquinone, a carrier of electrons in electron transport chain in prokaryotes. Menaquinone is important for a number of functions in the human body, including cell growth control, apoptosis, and the metabolism of calcium, to name a few. As the human body cannot create menaquinone, it derives it from intestinal bacteria, diet, or by converting plant vitamin K1 (phylloquinone). | ||
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| - | MqnA is the only known chorismate dehydratase. | ||
The example we are showing is from Streptomyces coelicolor. The other mutant MqnA are from Escherichia coli. | The example we are showing is from Streptomyces coelicolor. The other mutant MqnA are from Escherichia coli. | ||
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| + | The substrate for MqnA is chorismate. It is converted to menaquinone through two different pathways, the futalosine or the o-succinyl-benzoate pathways. On the futalosine pathway, chorismate is converted to 3-enolpyruvyl-benzoate (3-EPB) by our enzyme of interest. | ||
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== Biological relevance and broader implications == | == Biological relevance and broader implications == | ||
Revision as of 03:11, 25 April 2023
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Chorismate Dehydratase MqnA
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Goubran GF, Adekeye EO, Edwards MB. Melanoma of the face and mouth in Nigeria. A review and comment on three cases. Int J Oral Surg. 1978 Oct;7(5):453-62. PMID:102601 doi:10.1016/s0300-9785(78)80037-4
