7us2

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m (Protected "7us2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 7us2 is ON HOLD until Paper Publication
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==PARL-cleaved Skd3 (human ClpB) E455Q Nucleotide Binding Domain hexamer bound to ATPgammaS, open conformation==
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<StructureSection load='7us2' size='340' side='right'caption='[[7us2]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7us2]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7US2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7US2 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7us2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7us2 OCA], [https://pdbe.org/7us2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7us2 RCSB], [https://www.ebi.ac.uk/pdbsum/7us2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7us2 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CLPB_HUMAN CLPB_HUMAN] 3-methylglutaconic aciduria type 7;Autosomal dominant severe congenital neutropenia. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CLPB_HUMAN CLPB_HUMAN] May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117).<ref>PMID:31522117</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cheng Y]]
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[[Category: Chio US]]
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[[Category: Gupta A]]
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[[Category: Lentzsch AM]]
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[[Category: Lu C]]
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[[Category: Shan S-o]]
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[[Category: Siegel AS]]
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[[Category: Yu Z]]

Revision as of 16:56, 26 April 2023

PARL-cleaved Skd3 (human ClpB) E455Q Nucleotide Binding Domain hexamer bound to ATPgammaS, open conformation

PDB ID 7us2

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OCA

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