7xka

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'''Unreleased structure'''
 
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The entry 7xka is ON HOLD until Paper Publication
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==Structure of human beta2 adrenergic receptor bound to constrained epinephrine==
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<StructureSection load='7xka' size='340' side='right'caption='[[7xka]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors: Xu, X., Shonberg, J., Kaindl, J., Clark, M., Stobel, A., Maul, L., Mayer, D., Hubner, H., Venkatakrishnan, A., Dror, R., Kobilka, B.K., Sunahara, R., Liu, X., Gmeiner, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xka]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XKA FirstGlance]. <br>
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Description: Structure of human beta2 adrenergic receptor bound to constrained epinephrine
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G1I:(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol'>G1I</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xka OCA], [https://pdbe.org/7xka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xka RCSB], [https://www.ebi.ac.uk/pdbsum/7xka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xka ProSAT]</span></td></tr>
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[[Category: Dror, R]]
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</table>
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[[Category: Mayer, D]]
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== Function ==
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[[Category: Clark, M]]
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[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
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[[Category: Hubner, H]]
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== References ==
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[[Category: Shonberg, J]]
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<references/>
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[[Category: Venkatakrishnan, A]]
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__TOC__
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[[Category: Kaindl, J]]
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</StructureSection>
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[[Category: Gmeiner, P]]
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[[Category: Escherichia virus T4]]
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[[Category: Liu, X]]
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[[Category: Homo sapiens]]
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[[Category: Stobel, A]]
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[[Category: Large Structures]]
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[[Category: Xu, X]]
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[[Category: Clark M]]
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[[Category: Sunahara, R]]
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[[Category: Dror R]]
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[[Category: Kobilka, B.K]]
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[[Category: Gmeiner P]]
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[[Category: Maul, L]]
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[[Category: Hubner H]]
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[[Category: Kaindl J]]
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[[Category: Kobilka BK]]
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[[Category: Liu X]]
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[[Category: Maul L]]
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[[Category: Mayer D]]
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[[Category: Shonberg J]]
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[[Category: Stobel A]]
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[[Category: Sunahara R]]
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[[Category: Venkatakrishnan A]]
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[[Category: Xu X]]

Revision as of 16:58, 26 April 2023

Structure of human beta2 adrenergic receptor bound to constrained epinephrine

PDB ID 7xka

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