8afn

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'''Unreleased structure'''
 
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The entry 8afn is ON HOLD until Paper Publication
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==Small molecule stabilizer (compound 1) for ERalpha and 14-3-3==
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<StructureSection load='8afn' size='340' side='right'caption='[[8afn]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8afn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AFN FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O6C:1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide'>O6C</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8afn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8afn OCA], [https://pdbe.org/8afn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8afn RCSB], [https://www.ebi.ac.uk/pdbsum/8afn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8afn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arkin MR]]
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[[Category: Brunsveld L]]
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[[Category: Centorrino F]]
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[[Category: Kenanova DN]]
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[[Category: Neitz J]]
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[[Category: Ottmann C]]
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[[Category: Sijbesma E]]
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[[Category: Vickery H]]
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[[Category: Virta J]]
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[[Category: Visser EJ]]
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[[Category: Zhong M]]

Revision as of 17:03, 26 April 2023

Small molecule stabilizer (compound 1) for ERalpha and 14-3-3

PDB ID 8afn

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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