1kmz

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[[Image:1kmz.gif|left|200px]]
[[Image:1kmz.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1kmz", creates the "Structure Box" on the page.
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{{STRUCTURE_1kmz| PDB=1kmz | SCENE= }}
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|RELATEDENTRY=[[1kll|1KLL]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kmz OCA], [http://www.ebi.ac.uk/pdbsum/1kmz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kmz RCSB]</span>
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'''MOLECULAR BASIS OF MITOMYCIN C RESICTANCE IN STREPTOMYCES: CRYSTAL STRUCTURES OF THE MRD PROTEIN WITH AND WITHOUT A DRUG DERIVATIVE'''
'''MOLECULAR BASIS OF MITOMYCIN C RESICTANCE IN STREPTOMYCES: CRYSTAL STRUCTURES OF THE MRD PROTEIN WITH AND WITHOUT A DRUG DERIVATIVE'''
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[[Category: Sheffield, P.]]
[[Category: Sheffield, P.]]
[[Category: Sherman, D.]]
[[Category: Sherman, D.]]
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[[Category: anomalous diffraction]]
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[[Category: Anomalous diffraction]]
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[[Category: antibiotic resistance]]
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[[Category: Antibiotic resistance]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: domain swapping]]
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[[Category: Domain swapping]]
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[[Category: mitomycin c]]
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[[Category: Mitomycin c]]
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[[Category: p-staking]]
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[[Category: P-staking]]
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[[Category: sad]]
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[[Category: Sad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:55:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:50:46 2008''
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Revision as of 19:56, 2 May 2008

Image:1kmz.gif

Template:STRUCTURE 1kmz

MOLECULAR BASIS OF MITOMYCIN C RESICTANCE IN STREPTOMYCES: CRYSTAL STRUCTURES OF THE MRD PROTEIN WITH AND WITHOUT A DRUG DERIVATIVE


Overview

Mitomycin C (MC) is a potent anticancer agent. Streptomyces lavendulae, which produces MC, protects itself from the lethal effects of the drug by expressing several resistance proteins. One of them (MRD) binds MC and functions as a drug exporter. We report the crystal structure of MRD and its complex with an MC metabolite, 1,2-cis-1-hydroxy-2,7-diaminomitosene, at 1.5 A resolution. The drug is sandwiched by pi-stacking interactions of His-38 and Trp-108. MRD is a dimer. The betaalphabetabetabeta fold of the MRD molecule is reminiscent of methylmalonyl-CoA epimerase, bleomycin resistance proteins, glyoxalase I, and extradiol dioxygenases. The location of the binding site is identical to the ones in evolutionarily related enzymes, suggesting that the protein may have been recruited from a different metabolic pathway.

About this Structure

1KMZ is a Single protein structure of sequence from Streptomyces lavendulae. Full crystallographic information is available from OCA.

Reference

Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein., Martin TW, Dauter Z, Devedjiev Y, Sheffield P, Jelen F, He M, Sherman DH, Otlewski J, Derewenda ZS, Derewenda U, Structure. 2002 Jul;10(7):933-42. PMID:12121648 Page seeded by OCA on Fri May 2 22:55:58 2008

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