1kn3
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1kn3.gif|left|200px]] | [[Image:1kn3.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1kn3", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1kn3| PDB=1kn3 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)''' | '''Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)''' | ||
| Line 28: | Line 25: | ||
[[Category: Brady, R L.]] | [[Category: Brady, R L.]] | ||
[[Category: Simister, P C.]] | [[Category: Simister, P C.]] | ||
| - | [[Category: | + | [[Category: Cis-peptide]] |
| - | [[Category: | + | [[Category: Phosphatidylethanolamine binding]] |
| - | [[Category: | + | [[Category: Raf-1 kinase inhibitor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:56:05 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 19:56, 2 May 2008
Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)
Overview
Proteins from the PEBP (phosphatidylethanolamine-binding protein) family have been identified in a wide variety of species and are thought to regulate a range of intracellular signalling cascades. The rat homologue (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to negatively regulate the MAP kinase pathway through formation of inhibitory complexes with Raf-1 and MEK. The crystal structure of a new, murine member of the PEBP family, termed mPEBP-2, has been determined. On the basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar in structure to other PEBP proteins from human, bovine and plant sources. Regions of distinctive sequence associated with the PEBP-2 subset are discussed with reference to this structure.
About this Structure
1KN3 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family., Simister PC, Banfield MJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:12037323 Page seeded by OCA on Fri May 2 22:56:05 2008
