4xui
From Proteopedia
(Difference between revisions)
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<StructureSection load='4xui' size='340' side='right'caption='[[4xui]], [[Resolution|resolution]] 2.51Å' scene=''> | <StructureSection load='4xui' size='340' side='right'caption='[[4xui]], [[Resolution|resolution]] 2.51Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4xui]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4xui]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4pi4 4pi4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XUI FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2VC:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PYRIMIDIN-2-YLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2VC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2VC:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PYRIMIDIN-2-YLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2VC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xui OCA], [https://pdbe.org/4xui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xui RCSB], [https://www.ebi.ac.uk/pdbsum/4xui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xui ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Cruzipain]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Trycr]] | ||
| - | [[Category: McKerrow, J H]] | ||
| - | [[Category: Tochowicz, A]] | ||
| - | [[Category: Chagas disease]] | ||
| - | [[Category: Covalent reversible inhibitor]] | ||
| - | [[Category: Cruzain]] | ||
| - | [[Category: Cysteine protease]] | ||
| - | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
| - | [[Category: | + | [[Category: McKerrow JH]] |
| + | [[Category: Tochowicz A]] | ||
Revision as of 17:53, 26 April 2023
Crystal structure analysis of cruzain bound to the no-covalent analog of WRR-483 (WRR-669)
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