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4xui

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<StructureSection load='4xui' size='340' side='right'caption='[[4xui]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
<StructureSection load='4xui' size='340' side='right'caption='[[4xui]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xui]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4pi4 4pi4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xui]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4pi4 4pi4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XUI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2VC:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PYRIMIDIN-2-YLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2VC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2VC:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PYRIMIDIN-2-YLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2VC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pi3|4pi3]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xui OCA], [https://pdbe.org/4xui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xui RCSB], [https://www.ebi.ac.uk/pdbsum/4xui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xui ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xui OCA], [http://pdbe.org/4xui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xui RCSB], [http://www.ebi.ac.uk/pdbsum/4xui PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xui ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
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[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cruzipain]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trycr]]
 
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[[Category: McKerrow, J H]]
 
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[[Category: Tochowicz, A]]
 
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[[Category: Chagas disease]]
 
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[[Category: Covalent reversible inhibitor]]
 
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[[Category: Cruzain]]
 
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[[Category: Cysteine protease]]
 
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[[Category: Hydrolase-hydrolase inhibitor complex]]
 
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
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[[Category: Vinyl sulfone analog]]
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[[Category: McKerrow JH]]
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[[Category: Tochowicz A]]

Revision as of 17:53, 26 April 2023

Crystal structure analysis of cruzain bound to the no-covalent analog of WRR-483 (WRR-669)

PDB ID 4xui

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