4xyc

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<StructureSection load='4xyc' size='340' side='right'caption='[[4xyc]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='4xyc' size='340' side='right'caption='[[4xyc]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xyc]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XYC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xyc]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XYC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2K9:9-PHENYL-4H-IMIDAZO[1,2-A]INDENO[1,2-E]PYRAZIN-4-ONE'>2K9</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2K9:9-PHENYL-4H-IMIDAZO[1,2-A]INDENO[1,2-E]PYRAZIN-4-ONE'>2K9</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glnA1, glnA, MT2278 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyc OCA], [https://pdbe.org/4xyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xyc RCSB], [https://www.ebi.ac.uk/pdbsum/4xyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xyc ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyc OCA], [http://pdbe.org/4xyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xyc RCSB], [http://www.ebi.ac.uk/pdbsum/4xyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xyc ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLN1B_MYCTO GLN1B_MYCTO] Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Also plays a key role in controlling the ammonia levels within infected host cells and so contributes to the pathogens capacity to inhibit phagosome acidification and phagosome-lysosome fusion. Involved in cell wall biosynthesis via the production of the major component poly-L-glutamine (PLG). PLG synthesis in the cell wall occurs only in nitrogen limiting conditions and on the contrary high nitrogen conditions inhibit PLG synthesis.[UniProtKB:P9WN39]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Glutamine synthetase|Glutamine synthetase]]
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*[[Glutamine synthetase 3D structures|Glutamine synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glutamate--ammonia ligase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bacque, E]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Bauer, A]]
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[[Category: Bacque E]]
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[[Category: Couturier, C]]
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[[Category: Bauer A]]
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[[Category: Ganzhorn, A]]
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[[Category: Couturier C]]
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[[Category: Lagrange, S]]
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[[Category: Ganzhorn A]]
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[[Category: Llopart, S]]
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[[Category: Lagrange S]]
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[[Category: Morales, R]]
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[[Category: Llopart S]]
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[[Category: Nair, A]]
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[[Category: Morales R]]
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[[Category: Ppessegue, B]]
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[[Category: Nair A]]
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[[Category: Scheiper, B]]
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[[Category: Ppessegue B]]
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[[Category: Silve, S]]
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[[Category: Scheiper B]]
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[[Category: Poeverlein, c]]
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[[Category: Silve S]]
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[[Category: Atp binding]]
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[[Category: Poeverlein c]]
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[[Category: Ligase]]
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[[Category: Ligase-ligase inhibitor complex]]
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Revision as of 17:58, 26 April 2023

NANOMOLAR INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE 1: SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTALLOGRAPHIC STUDIES

PDB ID 4xyc

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