|
|
| Line 3: |
Line 3: |
| | <StructureSection load='4y2e' size='340' side='right'caption='[[4y2e]], [[Resolution|resolution]] 1.67Å' scene=''> | | <StructureSection load='4y2e' size='340' side='right'caption='[[4y2e]], [[Resolution|resolution]] 1.67Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4y2e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y2E FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4y2e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y2E FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUSP7, PYST2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2e OCA], [https://pdbe.org/4y2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y2e RCSB], [https://www.ebi.ac.uk/pdbsum/4y2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y2e ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2e OCA], [http://pdbe.org/4y2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y2e RCSB], [http://www.ebi.ac.uk/pdbsum/4y2e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y2e ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/DUS7_HUMAN DUS7_HUMAN]] Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.<ref>PMID:14603440</ref> | + | [https://www.uniprot.org/uniprot/DUS7_HUMAN DUS7_HUMAN] Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.<ref>PMID:14603440</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 21: |
Line 20: |
| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[Dual specificity phosphatase|Dual specificity phosphatase]] | + | *[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] |
| - | *[[MAP kinase phosphatase|MAP kinase phosphatase]]
| + | |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Austin, B P]] | + | [[Category: Austin BP]] |
| - | [[Category: Lountos, G T]] | + | [[Category: Lountos GT]] |
| - | [[Category: Tropea, J E]] | + | [[Category: Tropea JE]] |
| - | [[Category: Waugh, D S]] | + | [[Category: Waugh DS]] |
| - | [[Category: Dual specificity phosphatase]]
| + | |
| - | [[Category: Hydrolase]]
| + | |
| Structural highlights
Function
DUS7_HUMAN Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.[1]
Publication Abstract from PubMed
Human dual-specificity phosphatase 7 (DUSP7/Pyst2) is a 320-residue protein that belongs to the mitogen-activated protein kinase phosphatase (MKP) subfamily of dual-specificity phosphatases. Although its precise biological function is still not fully understood, previous reports have demonstrated that DUSP7 is overexpressed in myeloid leukemia and other malignancies. Therefore, there is interest in developing DUSP7 inhibitors as potential therapeutic agents, especially for cancer. Here, the purification, crystallization and structure determination of the catalytic domain of DUSP7 (Ser141-Ser289/C232S) at 1.67 A resolution are reported. The structure described here provides a starting point for structure-assisted inhibitor-design efforts and adds to the growing knowledge base of three-dimensional structures of the dual-specificity phosphatase family.
Structure of human dual-specificity phosphatase 7, a potential cancer drug target.,Lountos GT, Austin BP, Tropea JE, Waugh DS Acta Crystallogr F Struct Biol Commun. 2015 Jun 1;71(Pt 6):650-6. doi:, 10.1107/S2053230X1500504X. Epub 2015 May 20. PMID:26057789[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Levy-Nissenbaum O, Sagi-Assif O, Witz IP. Characterization of the dual-specificity phosphatase PYST2 and its transcripts. Genes Chromosomes Cancer. 2004 Jan;39(1):37-47. PMID:14603440 doi:http://dx.doi.org/10.1002/gcc.10295
- ↑ Lountos GT, Austin BP, Tropea JE, Waugh DS. Structure of human dual-specificity phosphatase 7, a potential cancer drug target. Acta Crystallogr F Struct Biol Commun. 2015 Jun 1;71(Pt 6):650-6. doi:, 10.1107/S2053230X1500504X. Epub 2015 May 20. PMID:26057789 doi:http://dx.doi.org/10.1107/S2053230X1500504X
|
