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4y2k

From Proteopedia

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Revision as of 18:04, 26 April 2023

reduced form of apo-GolB

Structural highlights

4y2k is a 1 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A140UHB4_SALTM

Publication Abstract from PubMed

The coordination bond between gold and sulfur (Au-S) has been widely studied and utilized in many fields. However, detailed investigations on the basic nature of this bond are still lacking. A gold-specific binding protein, GolB, was recently identified, providing a unique opportunity for the study of the Au-S bond at the molecular level. We probed the mechanical strength of the gold-sulfur bond in GolB using single-molecule force spectroscopy. We measured the rupture force of the Au-S bond to be 165 pN, much lower than Au-S bonds measured on different gold surfaces ( approximately 1000 pN). We further solved the structures of apo-GolB and Au(I)-GolB complex using X-ray crystallography. These structures showed that the average Au-S bond length in GolB is much longer than the reported average value of Au-S bonds. Our results highlight the dramatic influence of the unique biological environment on the stability and strength of metal coordination bonds in proteins.

Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB.,Wei W, Sun Y, Zhu M, Liu X, Sun P, Wang F, Gui Q, Meng W, Cao Y, Zhao J J Am Chem Soc. 2015 Dec 16;137(49):15358-61. doi: 10.1021/jacs.5b09895. Epub 2015, Dec 4. PMID:26636614^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Wei W, Sun Y, Zhu M, Liu X, Sun P, Wang F, Gui Q, Meng W, Cao Y, Zhao J. Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB. J Am Chem Soc. 2015 Dec 16;137(49):15358-61. doi: 10.1021/jacs.5b09895. Epub 2015, Dec 4. PMID:26636614 doi:http://dx.doi.org/10.1021/jacs.5b09895

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4y2k"

@@ Line 3: / Line 3: @@
 <StructureSection load='4y2k' size='340' side='right'caption='[[4y2k]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4y2k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y2K FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4y2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y2K FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4y2i|4y2i]], [[4y2m|4y2m]]</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2k OCA], [https://pdbe.org/4y2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y2k RCSB], [https://www.ebi.ac.uk/pdbsum/4y2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y2k ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STMDT2_03511 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2k OCA], [http://pdbe.org/4y2k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y2k RCSB], [http://www.ebi.ac.uk/pdbsum/4y2k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y2k ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A140UHB4_SALTM A0A140UHB4_SALTM]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Bacillus typhimurium loeffler 1892]]
 [[Category: Large Structures]]
-[[Category: Ma, L]]
+[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-[[Category: Wang, F]]
+[[Category: Ma L]]
-[[Category: Wei, W]]
+[[Category: Wang F]]
-[[Category: Zhao, J]]
+[[Category: Wei W]]
-[[Category: Gold binding protein]]
+[[Category: Zhao J]]
-[[Category: Metal transport]]
-[[Category: Redued form]]

4y2k

From Proteopedia

Revision as of 18:04, 26 April 2023

reduced form of apo-GolB

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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