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4y3b

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<StructureSection load='4y3b' size='340' side='right'caption='[[4y3b]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4y3b' size='340' side='right'caption='[[4y3b]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4y3b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y3B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4y3b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y3B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49F:(2S)-2-(2-METHOXYETHYL)PYRROLIDINE'>49F</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49F:(2S)-2-(2-METHOXYETHYL)PYRROLIDINE'>49F</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y3b OCA], [https://pdbe.org/4y3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y3b RCSB], [https://www.ebi.ac.uk/pdbsum/4y3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y3b ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y3b OCA], [http://pdbe.org/4y3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y3b RCSB], [http://www.ebi.ac.uk/pdbsum/4y3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y3b ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Microtubule-associated protein|Microtubule-associated protein]]
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*[[Microtubule-associated protein 3D structures|Microtubule-associated protein 3D structures]]
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*[[Tau protein|Tau protein]]
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*[[Tau protein 3D structures|Tau protein 3D structures]]
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bartel, M]]
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[[Category: Bartel M]]
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[[Category: Brunsveld, L]]
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[[Category: Brunsveld L]]
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[[Category: Milroy, L G]]
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[[Category: Milroy LG]]
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[[Category: Ottmann, C]]
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[[Category: Ottmann C]]
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[[Category: 14-3-3 fold]]
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[[Category: Adapter protein]]
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[[Category: All alpha-helical]]
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[[Category: Peptide binding protein]]
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[[Category: Protein-protein interaction]]
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[[Category: Signaling protein]]
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[[Category: Tau]]
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Revision as of 18:04, 26 April 2023

Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma

PDB ID 4y3b

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