1jxs
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(New page: 200px<br /> <applet load="1jxs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jxs" /> '''Solution Structure of the DNA-Binding Domai...)
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Revision as of 15:39, 12 November 2007
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Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor
Overview
Interleukin enhancer binding factor (ILF) binds to the interleukin-2, (IL-2) promoter and regulates IL-2 gene expression. In this study, the 3D, structure of the DNA-binding domain of ILF was determined by, multidimensional NMR spectroscopy. NMR structure analysis revealed that, the DNA-binding domain of ILF is a new member of the winged helix/forkhead, family, and that its wing 2 contains an extra alpha-helix. This is the, first study to report the presence of a C-terminal alpha-helix in place of, a typical wing 2 in a member of this family. This structural difference, may be responsible for the different DNA-binding specificity of ILF, compared to other winged helix/forkhead proteins. Our deletion studies of, the fragments of ILF also suggest that the C-terminal region plays a, regulatory role in DNA binding.
About this Structure
1JXS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)., Liu PP, Chen YC, Li C, Hsieh YH, Chen SW, Chen SH, Jeng WY, Chuang WJ, Proteins. 2002 Dec 1;49(4):543-53. PMID:12402362
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