1kou

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[[Image:1kou.gif|left|200px]]
[[Image:1kou.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1kou |SIZE=350|CAPTION= <scene name='initialview01'>1kou</scene>, resolution 1.16&Aring;
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The line below this paragraph, containing "STRUCTURE_1kou", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene>, <scene name='pdbligand=NBU:N-BUTANE'>NBU</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= PYP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1053 Halorhodospira halophila])
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|DOMAIN=
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{{STRUCTURE_1kou| PDB=1kou | SCENE= }}
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|RELATEDENTRY=[[1d7e|1D7E]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kou OCA], [http://www.ebi.ac.uk/pdbsum/1kou PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kou RCSB]</span>
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}}
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'''Crystal Structure of the Photoactive Yellow Protein Reconstituted with Caffeic Acid at 1.16 A Resolution'''
'''Crystal Structure of the Photoactive Yellow Protein Reconstituted with Caffeic Acid at 1.16 A Resolution'''
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[[Category: Hellingwerf, K J.]]
[[Category: Hellingwerf, K J.]]
[[Category: Joshua-Tor, L.]]
[[Category: Joshua-Tor, L.]]
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[[Category: photoreceptor]]
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[[Category: Photoreceptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:59:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:51:30 2008''
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Revision as of 19:59, 2 May 2008

Image:1kou.gif

Template:STRUCTURE 1kou

Crystal Structure of the Photoactive Yellow Protein Reconstituted with Caffeic Acid at 1.16 A Resolution


Overview

A structural study is described of the photoactive yellow protein (PYP) reconstituted with the chromophore derivative 3,4-dihydroxycinnamic acid. The crystal structure of PYP reconstituted with this chromophore at 1.16 A resolution is reported in space group P6(5). This is the first high-resolution structure of a photoreceptor containing a modified chromophore. The introduction of an extra hydroxyl group in the native chromophore (i.e. p-coumaric acid) appears to perturb the structure of the hybrid yellow protein only slightly. The chromophore is bound by the protein in two different conformations, separated by a rotation of 180 degrees of the catechol ring. In combination with available spectroscopic data, it is concluded that the caffeic acid chromophore binds to the protein in a strained conformation, which leads to a faster ejection from the chromophore-binding pocket upon pB formation.

About this Structure

1KOU is a Single protein structure of sequence from Halorhodospira halophila. Full crystallographic information is available from OCA.

Reference

Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 A resolution., van Aalten DM, Crielaard W, Hellingwerf KJ, Joshua-Tor L, Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):585-90. Epub 2002, Mar 22. PMID:11914481 Page seeded by OCA on Fri May 2 22:59:53 2008

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