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4yek

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<StructureSection load='4yek' size='340' side='right'caption='[[4yek]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='4yek' size='340' side='right'caption='[[4yek]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yek]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YEK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YEK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yek]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YEK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xr5|4xr5]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yek OCA], [https://pdbe.org/4yek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yek RCSB], [https://www.ebi.ac.uk/pdbsum/4yek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yek ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_phosphorylase Thymidine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.4 2.4.2.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yek OCA], [http://pdbe.org/4yek PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yek RCSB], [http://www.ebi.ac.uk/pdbsum/4yek PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yek ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TYPH_SALTY TYPH_SALTY]] The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
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[https://www.uniprot.org/uniprot/TYPH_SALTY TYPH_SALTY] The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thymidine phosphorylase]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Balaev, V V]]
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[[Category: Balaev VV]]
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[[Category: Betzel, C]]
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[[Category: Betzel C]]
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[[Category: Gabdulkhakov, A G]]
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[[Category: Gabdulkhakov AG]]
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[[Category: Lashkov, A A]]
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[[Category: Lashkov AA]]
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[[Category: Mikhailov, A M]]
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[[Category: Mikhailov AM]]
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[[Category: Metabolism]]
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[[Category: Nucleoside]]
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[[Category: Transferase]]
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Revision as of 08:11, 3 May 2023

X-ray structure of the thymidine phosphorylase from Salmonella typhimurium in complex with thymidine

PDB ID 4yek

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