1kps

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1kps.gif|left|200px]]
[[Image:1kps.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1kps |SIZE=350|CAPTION= <scene name='initialview01'>1kps</scene>, resolution 2.50&Aring;
+
The line below this paragraph, containing "STRUCTURE_1kps", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= UBC9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RANGAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1kps| PDB=1kps | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kps OCA], [http://www.ebi.ac.uk/pdbsum/1kps PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kps RCSB]</span>
+
-
}}
+
'''Structural Basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin conjugating enzyme Ubc9 and RanGAP1'''
'''Structural Basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin conjugating enzyme Ubc9 and RanGAP1'''
Line 31: Line 28:
[[Category: Matunis, M J.]]
[[Category: Matunis, M J.]]
[[Category: Sampson, D A.]]
[[Category: Sampson, D A.]]
-
[[Category: conjugating enzyme]]
+
[[Category: Conjugating enzyme]]
-
[[Category: e2]]
+
[[Category: E2]]
-
[[Category: ligase]]
+
[[Category: Ligase]]
-
[[Category: small ubiquitin-like modifier]]
+
[[Category: Small ubiquitin-like modifier]]
-
[[Category: sumo]]
+
[[Category: Sumo]]
-
[[Category: thioester]]
+
[[Category: Thioester]]
-
[[Category: ubiquitin]]
+
[[Category: Ubiquitin]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:01:29 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:51:51 2008''
+

Revision as of 20:01, 2 May 2008

Image:1kps.gif

Template:STRUCTURE 1kps

Structural Basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin conjugating enzyme Ubc9 and RanGAP1


Overview

E2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues directly or through E3-mediated reactions. The small ubiquitin-like modifier SUMO regulates nuclear transport, stress response, and signal transduction in eukaryotes and is essential for cell-cycle progression in yeast. In contrast to most ubiquitin conjugation, the SUMO E2 enzyme Ubc9 is sufficient for substrate recognition and lysine modification of known SUMO targets. Crystallographic analysis of a complex between mammalian Ubc9 and a C-terminal domain of RanGAP1 at 2.5 A reveals structural determinants for recognition of consensus SUMO modification sequences found within SUMO-conjugated proteins. Structure-based mutagenesis and biochemical analysis of Ubc9 and RanGAP1 reveal distinct motifs required for substrate binding and SUMO modification of p53, IkappaBalpha, and RanGAP1.

About this Structure

1KPS is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1., Bernier-Villamor V, Sampson DA, Matunis MJ, Lima CD, Cell. 2002 Feb 8;108(3):345-56. PMID:11853669 Page seeded by OCA on Fri May 2 23:01:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kps"
Personal tools