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4ypl

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<StructureSection load='4ypl' size='340' side='right'caption='[[4ypl]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
<StructureSection load='4ypl' size='340' side='right'caption='[[4ypl]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ypl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_baa-399 Atcc baa-399]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YPL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ypl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Meiothermus_taiwanensis Meiothermus taiwanensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YPL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4KZ:N-[(1R)-1-(DIHYDROXYBORANYL)-2-PHENYLETHYL]-NALPHA-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE'>4KZ</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4KZ:N-[(1R)-1-(DIHYDROXYBORANYL)-2-PHENYLETHYL]-NALPHA-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE'>4KZ</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ypm|4ypm]], [[4ypn|4ypn]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ypl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ypl OCA], [https://pdbe.org/4ypl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ypl RCSB], [https://www.ebi.ac.uk/pdbsum/4ypl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ypl ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lonA1, lon ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=172827 ATCC BAA-399])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ypl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ypl OCA], [http://pdbe.org/4ypl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ypl RCSB], [http://www.ebi.ac.uk/pdbsum/4ypl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ypl ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A059VAZ3_9DEIN A0A059VAZ3_9DEIN]] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.[HAMAP-Rule:MF_01973]
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[https://www.uniprot.org/uniprot/A0A059VAZ3_9DEIN A0A059VAZ3_9DEIN] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.[HAMAP-Rule:MF_01973]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc baa-399]]
 
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[[Category: Endopeptidase La]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chang, C I]]
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[[Category: Meiothermus taiwanensis]]
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[[Category: Lin, C C]]
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[[Category: Chang C-I]]
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[[Category: Aaa+ domain]]
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[[Category: Lin C-C]]
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[[Category: Adp]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Lon protease]]
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[[Category: Mmh8709]]
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Revision as of 08:24, 3 May 2023

Crystal structure of a hexameric LonA protease bound to three ADPs

PDB ID 4ypl

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