4yqf

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==GTPase domain of Human Septin 9==
==GTPase domain of Human Septin 9==
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<StructureSection load='4yqf' size='340' side='right' caption='[[4yqf]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
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<StructureSection load='4yqf' size='340' side='right'caption='[[4yqf]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yqf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YQF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yqf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YQF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEPT9, KIAA0991, MSF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqf OCA], [https://pdbe.org/4yqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yqf RCSB], [https://www.ebi.ac.uk/pdbsum/4yqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqf OCA], [http://pdbe.org/4yqf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yqf RCSB], [http://www.ebi.ac.uk/pdbsum/4yqf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqf ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN]] Neuralgic amyotrophy. A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1.<ref>PMID:10339604</ref> The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN] Neuralgic amyotrophy. A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1.<ref>PMID:10339604</ref> The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
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[https://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN] Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Araujo, A P.U]]
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[[Category: Large Structures]]
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[[Category: Garratt, R C]]
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[[Category: Araujo APU]]
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[[Category: Leonardo, D A]]
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[[Category: Garratt RC]]
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[[Category: Macedo, J N]]
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[[Category: Leonardo DA]]
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[[Category: Matos, S O]]
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[[Category: Macedo JN]]
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[[Category: Pereira, H M]]
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[[Category: Matos SO]]
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[[Category: Cytoskeleton component. septin gtpase]]
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[[Category: Pereira HM]]
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[[Category: Hydrolase]]
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Revision as of 08:25, 3 May 2023

GTPase domain of Human Septin 9

PDB ID 4yqf

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