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4yro

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==Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 5-bromo-6-methylpyridin-2-amine (Chem 491)==
==Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 5-bromo-6-methylpyridin-2-amine (Chem 491)==
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<StructureSection load='4yro' size='340' side='right' caption='[[4yro]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4yro' size='340' side='right'caption='[[4yro]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YRO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YRO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4JO:5-BROMO-6-METHYLPYRIDIN-2-AMINE'>4JO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JO:5-BROMO-6-METHYLPYRIDIN-2-AMINE'>4JO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yp0|4yp0]], [[4ypf|4ypf]], [[4yrc|4yrc]], [[4yre|4yre]], [[4yrf|4yrf]], [[4yrg|4yrg]], [[4yri|4yri]], [[4yrj|4yrj]], [[4yrk|4yrk]], [[4yrl|4yrl]], [[4yrm|4yrm]], [[4yrn|4yrn]], [[4yrp|4yrp]], [[4yrq|4yrq]], [[4yrr|4yrr]], [[4yrs|4yrs]], [[4yrt|4yrt]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yro OCA], [https://pdbe.org/4yro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yro RCSB], [https://www.ebi.ac.uk/pdbsum/4yro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yro ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tc00.1047053507019.40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine--tRNA_ligase Histidine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.21 6.1.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yro OCA], [http://pdbe.org/4yro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yro RCSB], [http://www.ebi.ac.uk/pdbsum/4yro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yro ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4DA54_TRYCC Q4DA54_TRYCC]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4yro" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4yro" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Histidine--tRNA ligase]]
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[[Category: Large Structures]]
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[[Category: Trycc]]
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[[Category: Trypanosoma cruzi strain CL Brener]]
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[[Category: Hol, W G.J]]
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[[Category: Hol WGJ]]
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[[Category: Koh, C Y]]
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[[Category: Koh C-Y]]
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[[Category: Aar]]
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[[Category: Aminoacyl-trna synthetase]]
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[[Category: Hisr]]
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[[Category: Ligase]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Protein-inhibitor complex]]
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[[Category: Trypanosoma cruzi]]
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Revision as of 08:28, 3 May 2023

Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 5-bromo-6-methylpyridin-2-amine (Chem 491)

PDB ID 4yro

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