4ys7

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==Co-crystal structure of 2-[2-(5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-3-methyl-3H-imidazo[4,5-f]quinoline (compound 39) with PDE10A==
==Co-crystal structure of 2-[2-(5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-3-methyl-3H-imidazo[4,5-f]quinoline (compound 39) with PDE10A==
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<StructureSection load='4ys7' size='340' side='right' caption='[[4ys7]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4ys7' size='340' side='right'caption='[[4ys7]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ys7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YS7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ys7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YS7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GK:2-[2-(5,8-DIMETHYL[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-2-YL)ETHYL]-3-METHYL-3H-IMIDAZO[4,5-F]QUINOLINE'>4GK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4GK:2-[2-(5,8-DIMETHYL[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-2-YL)ETHYL]-3-METHYL-3H-IMIDAZO[4,5-F]QUINOLINE'>4GK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yqh|4yqh]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ys7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ys7 OCA], [https://pdbe.org/4ys7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ys7 RCSB], [https://www.ebi.ac.uk/pdbsum/4ys7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ys7 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ys7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ys7 OCA], [http://pdbe.org/4ys7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ys7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ys7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ys7 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ys7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ys7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Burdi, D F]]
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[[Category: Large Structures]]
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[[Category: Herman, L]]
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[[Category: Burdi DF]]
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[[Category: Wang, T]]
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[[Category: Herman L]]
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[[Category: Co-crystal]]
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[[Category: Wang T]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor]]
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[[Category: Pde10a]]
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Revision as of 08:28, 3 May 2023

Co-crystal structure of 2-[2-(5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-3-methyl-3H-imidazo[4,5-f]quinoline (compound 39) with PDE10A

PDB ID 4ys7

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