Journal:Proteins:3

Newly Born proteins, or orphan proteins, have no sequence homology to other proteins and occur in single species or within a taxonomically restricted gene family

Never Born proteins are random polypeptides with amino acid content similar to that of native proteins.

Can recently developed AI/Deep Learning tools for predicting 3D protein structures like:

• AlphaFold2 (AF2)
• RoseTTAFold (RTF)
• Evolutionary Scale Modeling (ESM-2)

be useful to see if Newly Born proteins are similar to Never Born proteins?

Sequences of Never Born proteins by Tretyachenko et al. ref 29133927

showed experimentally that some folded into compact structures [Fig. 1], while others belong to the category of intrinsically disordered proteins (IDPs)[36] [Fig. 2].

< and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function

Disease

Relevance

Structural highlights

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