1kql
From Proteopedia
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'''Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution''' | '''Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution''' | ||
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[[Category: Strand, J.]] | [[Category: Strand, J.]] | ||
[[Category: Tobacman, L S.]] | [[Category: Tobacman, L S.]] | ||
| - | [[Category: | + | [[Category: Coiled coil]] |
| - | [[Category: | + | [[Category: Contractile protein]] |
| - | [[Category: | + | [[Category: Four-helix bundle]] |
| - | [[Category: | + | [[Category: Muscle regulation]] |
| - | [[Category: | + | [[Category: Thin filament]] |
| - | [[Category: | + | [[Category: Tropomyosin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:03:16 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 20:03, 2 May 2008
Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution
Overview
Contraction in striated and cardiac muscles is regulated by the motions of a Ca(2+)-sensitive tropomyosin/troponin switch. In contrast, troponin is absent in other muscle types and in nonmuscle cells, and actomyosin regulation is myosin-linked. Here we report an unusual crystal structure at 2.7 A of the C-terminal 31 residues of rat striated-muscle alpha-tropomyosin (preceded by a fragment of the GCN4 leucine zipper). The C-terminal 22 residues (263-284) of the structure do not form a two-stranded alpha-helical coiled coil as does the rest of the molecule, but here the alpha-helices splay apart and are stabilized by the formation of a tail-to-tail dimer with a symmetry-related molecule. The site of splaying involves a small group of destabilizing core residues that is present only in striated muscle tropomyosin isoforms. These results reveal a specific recognition site for troponin T and clarify the physical basis for the unique regulatory mechanism of striated muscles.
About this Structure
1KQL is a Single protein structure of sequence from Saccharomyces cerevisiae and rattus norvegicus. Full crystallographic information is available from OCA.
Reference
The crystal structure of the C-terminal fragment of striated-muscle alpha-tropomyosin reveals a key troponin T recognition site., Li Y, Mui S, Brown JH, Strand J, Reshetnikova L, Tobacman LS, Cohen C, Proc Natl Acad Sci U S A. 2002 May 28;99(11):7378-83. PMID:12032291 Page seeded by OCA on Fri May 2 23:03:16 2008
