8bpb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the human SIN3B histone deacetylase core complex at 2.8 Angstrom== | |
| - | + | <StructureSection load='8bpb' size='340' side='right'caption='[[8bpb]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bpb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpb OCA], [https://pdbe.org/8bpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpb RCSB], [https://www.ebi.ac.uk/pdbsum/8bpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpb ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SIN3B_HUMAN SIN3B_HUMAN] SIN3A-related intellectual disability syndrome due to a point mutation. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SIN3B_HUMAN SIN3B_HUMAN] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.[UniProtKB:Q62141] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Alfieri C]] | ||
| + | [[Category: Koliopolous MG]] | ||
| + | [[Category: Muhammad R]] | ||
| + | [[Category: Wan MSM]] | ||
Revision as of 06:51, 10 May 2023
Cryo-EM structure of the human SIN3B histone deacetylase core complex at 2.8 Angstrom
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