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4yw7

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<StructureSection load='4yw7' size='340' side='right'caption='[[4yw7]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='4yw7' size='340' side='right'caption='[[4yw7]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yw7]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YW7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yw7]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YW7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J0:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLPROPANE-3,1-DIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4J0:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLPROPANE-3,1-DIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lecA, pa1L, PA2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yw7 OCA], [https://pdbe.org/4yw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yw7 RCSB], [https://www.ebi.ac.uk/pdbsum/4yw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yw7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yw7 OCA], [http://pdbe.org/4yw7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yw7 RCSB], [http://www.ebi.ac.uk/pdbsum/4yw7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yw7 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE]] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
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[https://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4yw7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4yw7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Galactose-binding lectin|Galactose-binding lectin]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bergmann, M]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Darbre, T]]
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[[Category: Bergmann M]]
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[[Category: Gillon, E]]
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[[Category: Darbre T]]
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[[Category: Imberty, A]]
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[[Category: Gillon E]]
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[[Category: Jin, X]]
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[[Category: Imberty A]]
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[[Category: Michaud, G]]
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[[Category: Jin X]]
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[[Category: Pieters, R]]
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[[Category: Michaud G]]
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[[Category: Reymond, J L]]
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[[Category: Pieters R]]
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[[Category: Stocker, A]]
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[[Category: Reymond J-L]]
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[[Category: Visini, R]]
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[[Category: Stocker A]]
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[[Category: Galactoside]]
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[[Category: Visini R]]
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[[Category: Lectin]]
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[[Category: Sugar binding protein]]
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Revision as of 07:28, 10 May 2023

Structural Insight into Divalent Galactoside Binding to Pseudomonas aeruginosa lectin LecA

PDB ID 4yw7

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