4z2x

<StructureSection load='4z2x' size='340' side='right' caption='[[4z2x]], [[Resolution|resolution]] 2.15&Aring;' scene=''>

<table><tr><td colspan='2'>[[4z2x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2X FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">U2af2, U2af65 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2x OCA], [http://pdbe.org/4z2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2x RCSB], [http://www.ebi.ac.uk/pdbsum/4z2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2x ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/U2AF2_MOUSE U2AF2_MOUSE]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10 (By similarity).

[[Category: Lk3 transgenic mice]]

[[Category: Structural genomic]]

[[Category: Tcell]]