This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4z33
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='4z33' size='340' side='right'caption='[[4z33]], [[Resolution|resolution]] 2.45Å' scene=''> | <StructureSection load='4z33' size='340' side='right'caption='[[4z33]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4z33]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4z33]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z33 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IP2:D-MYO-INOSITOL-4,5-BISPHOSPHATE'>IP2</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IP2:D-MYO-INOSITOL-4,5-BISPHOSPHATE'>IP2</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z33 OCA], [https://pdbe.org/4z33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z33 RCSB], [https://www.ebi.ac.uk/pdbsum/4z33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z33 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| - | + | ||
| - | + | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Egea-Jimenez | + | [[Category: Egea-Jimenez AL]] |
| - | [[Category: Gallardo | + | [[Category: Gallardo R]] |
| - | [[Category: Garcia-Pino | + | [[Category: Garcia-Pino A]] |
| - | [[Category: Ivarsson | + | [[Category: Ivarsson Y]] |
| - | [[Category: Kashyap | + | [[Category: Kashyap R]] |
| - | [[Category: Loris | + | [[Category: Loris R]] |
| - | [[Category: Rousseau | + | [[Category: Rousseau F]] |
| - | [[Category: Schymkowitz | + | [[Category: Schymkowitz J]] |
| - | [[Category: Wawrzyniak | + | [[Category: Wawrzyniak AM]] |
| - | [[Category: Zimmermann | + | [[Category: Zimmermann P]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 07:37, 10 May 2023
Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2
| |||||||||||
